Collectively, the myeloid infiltrationwas significantly increasedat the site of tumorigenesis as the tumor progressed; nevertheless,the proportion of CD206+ macrophages tended to remain constant.The CD206+ macrophage population highly expressed FRβ.At the late stages of tumor formation, FRβ was upregulated byeither CD206+ or CD206– classical macrophagesin the tumor microenvironment. This evidence concerns the gene FOLR2 and neoplasm.