This suppressive phenotype, however, is not present in all ccRCC cell lines, as knockout of ANGPTL4 or inhibition by treatment with anti-cANGPTL4 inhibits tumor growth in the 786O tumor model, a model with mutant VHL (Supplementary Fig. S2G and S2H). This evidence concerns the gene ANGPTL4 and nonpapillary renal cell carcinoma.