Knockout of ANGPTL4 in 786O cells which have mutant VHL, significantly reduced tumor growth (Supplementary Fig. S2G) as did treatment with anti-cANGPTL4 antibodies (Supplementary Fig. S2H), suggesting that in 786O cells, the proangiogenic tumor-promoting function of cANGPTL4 may be predominant over the tumor suppressive function. Here, VHL is linked to neoplasm.