TYR and melanoma: However, the most extensively studied heterocyclic series revolved around a 2‐aminothiazole core, following the early identification of compound 75, which showed good potency against mTYR (IC50=0.1 μM) and effectively reduced pigmentation in MNT‐1 human melanoma cells (83 % at 15 μM).[146] A more recent study relied on this heterocyclic framework to inhibit hTYR isolated from TYR‐expressing HEK‐293 cells.