Importantly, compared with those in healthy mice, the pathways enriched in liver genes whose transcripts were upregulated in PBC-FMT mice included nearly all pathways (except the phospholipase D signaling pathway and microRNAs in cancer) identified in 2OA-BSA–treated mice and included new pathways related to asthma, infectious diseases (pertussis, legionellosis, amoebiasis, and herpes simplex infection), fluid shear stress and atherosclerosis, and the AGE-RAGE signaling pathway in diabetic complications. The gene discussed is RENBP; the disease is pertussis.