TNF and autoimmune thyroid disease: However, liver genes that were upregulated in the 2OA-PBC–FMT group were enriched in 61 pathways, including 25 disease pathways, such as autoimmune thyroid disease, rheumatoid arthritis, asthma, systemic lupus erythematosus, and primary immunodeficiency; 16 immune system pathways, such as antigen processing and presentation and Th17 cell differentiation; and pathways such as NF-kappa B, TNF, JAK-STAT, p53, cell cycle, apoptosis and necroptosis.