CHIP and Hsp70 play crucial roles in regulating Tau ubiquitination, degradation, and aggregation. CHIP acts as an ubiquitin ligase for Tau and is involved in Tau degradation, while Hsp70 can reduce the accumulation of insoluble Tau aggregates. The balance between CHIP and Hsp70 levels is essential for maintaining normal Tau physiology and preventing Tau aggregation and toxicity in AD. The gene discussed is STUB1; the disease is Alzheimer disease.