PRKN and Parkinson disease: The interaction between Ser65‐phosphorylated ubiquitin and parkin initiates a significant conformational change in parkin. These ubiquitin chains, when phosphorylated at Ser65, exhibit resistance to deubiquitination through various enzymes. Deficiencies in ubiquitin phosphorylation‐dependent mitophagy are increasingly linked to the pathogenesis of PD.