Parkin affects RIPK1 in Parkinson's disease by mediating site‐specific ubiquitination of RIPK1, which influences signaling pathways like NF‐κB and MAPK and plays a role in regulating cell death processes associated with PD. Furthermore, Parkin prevents the formation of the RIPK1–RIPK3 complex by promoting polyubiquitination of RIPK3, thereby negatively regulating necroptosis in inflammation and tumorigenesis. The gene discussed is NFKB1; the disease is Parkinson disease.