In HD, elevated expression of the protein kinase CK2α and the E3 ligase component FBXW7 promotes the phosphorylation‐dependent degradation of HSF1. FBXW7 depletion has been shown to suppress increased invasion, indicating that HSF1 is a critical FBXW7 substrate involved in this process. This evidence concerns the gene FBXW7 and Huntington disease.