USP8 and Parkinson disease: α‐Syn is a substrate for the deubiquitinase Usp8, which interacts with and deconjugates K63‐linked ubiquitin chains on α‐syn, prolonging its half‐life and increasing its toxicity. Usp8 is upregulated in neurons with Lewy body pathology, and its increased expression can lead to the accumulation of α‐syn, which is associated with PD.