Among the proteins that undergo SUMOylation, α‐syn, DJ‐1, Parkin, dynamin‐related protein 1 (Drp1), and peroxisome proliferation ‐ activated receptor‐ gama‐ coactivator (PGC‐1α) have been found to exhibit a high frequency of occurrence and are involved in the pathogenic processes of PD.38, 92. This evidence concerns the gene PPARGC1A and Parkinson disease.