LRRK2 and Parkinson disease: The G2385R variant of LRRK2 in PD has significant implications. Studies have shown that this variant inhibits LRRK2 dimerization, destabilizes the protein, and enhances its kinase activity. Moreover, the G2385R variant promotes LRRK2 protein turnover by increasing binding affinity to Hsc70 and CHIP, leading to enhanced intracellular degradation of LRRK2.