Nuclear α‐syn operates through a similar mechanism by binding to the gene promoter region of peroxisome PGC‐1α, a TF of the mitochondria that, when dysfunctional, leads to oxidative stress and mitochondrial dysfunction in the pathophysiology of PD; in addition, it inhibits histone acetylation and suppresses PGC‐1α expression. This evidence concerns the gene PPARGC1A and Parkinson disease.