PRNP and prion disease: Drugs known to induce Hsp70 expression, such as 17-DMAG and dexamethasone, have been explored for their therapeutic potential in treating prion diseases in Drosophila. However, significant outcomes were not observed when the individual treatment was used; however, their combination significantly increased the level of inducible Hsp70, decreased PrP expression, inhibited the accumulation of PrPSc, and enhanced locomotor activity (Zhang et al., 2014).