Antiphospholipid syndrome (APS) is a prothrombotic autoimmune disorder that is characterized by obstetric or thrombotic morbidity in the persistent presence of antiphospholipid antibodies (APLAs).1The main autoantigen these antibodies are directed against is circulating plasma protein β-2-glycoprotein 1 (β2GP-1). The gene discussed is APOH; the disease is Autoimmunity.