Furthermore, SAA1 knockdown, like hepatic Surf4 deficiency, substantially reduces liver fibrosis in Surf4flox mice, but has no detectable effect on liver fibrosis in Surf4LKO mice, suggesting the contribution of SAA1 to Surf4 deficiency-induced alleviation of liver fibrosis in mice. The gene discussed is SURF4; the disease is Hepatic fibrosis.