Lack of Surf4 also significantly reduced the expression of liver fibrosis markers (Col1a, Acta2/α-Sma) and inflammation markers (Il-1β and Tnf-α) at mRNA and protein levels in male and female Surf4LKO mice (Fig. 3E and F and Fig. S4E and F). Here, ACTA2 is linked to Hepatic fibrosis.