As shown in Fig. 6B and C, knockdown of SAA1 significantly decreased liver fibrosis in Surf4flox mice but not in Surf4LKO mice compared with corresponding controls receiving AAV-shRNA NC, as evidenced by Masson’s and Picrosirius red staining (column 1 vs. 2 and column 3 vs. 4). This evidence concerns the gene SAA1 and Hepatic fibrosis.