Compounds such as Tanshinone IIA (72) and Salidroside (73) have been shown to inhibit cellular death and delay DN progression by targeting the TXNIP/NLRP3 pathway.Calycosins, principal components of Astragalus, exhibit multiple pharmacological effects, including the ability to improve renal function in DN. The gene discussed is TXNIP; the disease is liver dysplastic nodule.