Univariate analysis revealed that patients with a larger tumor size (P=0.001), FTC (P=0.015), multicentricity (P=0.035), extrathyroidal invasion (P=0.003), stage T4 (P=0.000), stage N1b (P=0.003), a high recurrence risk (P=0.000), ps-Tg ≥20 ng/mL (P=0.000), IR as the therapeutic response to initial RAIT (P=0.000), a greater total number of RAIT sessions (P=0.000), and greater total 131I activity (P=0.000) had a higher probability of IR (Table 2). The gene discussed is TG; the disease is neoplasm.