Pearson correlation analysis of the ISG expression levels revealed significant positive correlations between IFN-α, IFN-β, RSAD2, IFI44L, and NMI and between IRF5, IRF8, and IFI27 at pre-SC (Figure 2A), which were lost after HIV infection (Figure 2B and Supplementary Figure 2). This evidence concerns the gene IRF5 and HIV infectious disease.