ISG15 and IFI27 expression significantly increased after HIV infection starting at the early time point 5–9 months post-SC (Figure 1), whereas increased IFI44L and RSAD2 expression was observed at 2 and 6 years post-SC; however, this increase was only significant for IFI44L during the chronic phase of infection (Figure 1). Here, RSAD2 is linked to HIV infectious disease.