Compared to peritumoral and normal tissues, the expression of CD163 (t=26.85, p <0.001; t=27.15, p <0.001), Foxp3 (t=25.70, p <0.001; t=25.76, p <0.001), and ICOS (t=24.21, p <0.001; t=24.22, p <0.001) increased in CRC tissues. This evidence concerns the gene ICOS and colorectal carcinoma.