As shown in Table 2, in CRC tissues, CD163 was related to tumor TNM stage (χ2 = 23.974, p <0.01), vascular cancer emboli (χ2 = 6.201, p =0.010), neural invasion (χ2 = 4.328, p =0.029), lymph node metastasis (χ2 = 15.663, p =0.002), and distant metastasis (χ2 = 4.273, p =0.029). The gene discussed is CD163; the disease is metastatic malignant neoplasm in the lymph nodes.