FOXP3 and metastatic malignant neoplasm in the lymph nodes: By comparing the expression levels of these three proteins in TNM stages of CRC patients, it was observed that with the increase in tumor TNM stage, invasion depth, lymph node metastasis, and distant metastasis, the expression levels of CD163 and Foxp3 significantly increased in TNM stages and distant metastasis (Figures 6A, D, E, H).