Drawing from two distinct knockout models, namely T-cell-specific TSC1 knockout (TSC1-KO) mice and T-cell-specific mTOR knockout (mTOR-KO) mice, we investigated the mTOR pathway's regulatory function on the autophagy level of CD4+ T cells and CTLA4 accumulation in sepsis (Figures 3(a) and 3(b)). This evidence concerns the gene TSC1 and Sepsis.