A particular study identified 25 differentially expressed miRNAs in the plasma of patients with sepsis compared to healthy individuals, among them, downregulation of miR-335-5p, miR-331-3p, and miR-301a-3p was identified as critical prognostic indicators, potentially affecting the progression of sepsis through the MAPK and PI3K-Akt pathways [27]. The gene discussed is AKT1; the disease is Sepsis.