CD4 and infection: The virus multiplies within cells, generating new viral proteins, with MHC class I presenting antigens to T CD8+ cells for targeted cell destruction and MHC class II activating T CD4+ cells influencing immune responses through cytokines, controlling infection and inhibiting viral replication (Kori et al., 2015; Heath et al., 2016; de Sousa Dias et al., 2018).