TNF-α is an important pro-inflammatory factor, and previous studies have shown that TNF-α can impair endothelial function, induce atherosclerosis and insulin resistance, accelerate the proliferation of smooth muscle cells, and promote the release of platelet growth factor from platelets, accelerating the progression of vascular lesions (Buckley et al., 2005). The gene discussed is TNF; the disease is atherosclerosis.