The factors contributing to the increased risk of SLE are not limited to single nucleotide polymorphisms (SNPs) but include several autophagy-related genes such as Atg5 (80), Atg7 (80), LRRK2 (81), IRGM (80), DRAM1 (82), CDKN1B (82), MTMR3 (83), and APOL1 (84). The gene discussed is ATG5; the disease is systemic lupus erythematosus.