The number of plasma cells, CD4−CD8−, CD4+ and CD8+ T cells were reduced. Albuminuria, serum anti-dsDNA antibodies, BAFF, and glomerular immune complex deposits were reduced, and lupus symptoms were improved.CD4+ and CD8+ T cells increased cell death, mitochondria and endoplasmic reticulum content, calcium flux change. This evidence concerns the gene CD4 and systemic lupus erythematosus.