Blocking ROCK and RhoA revealed that the alcohol-induced impairment of alveolar macrophages was independent of RhoA, suggesting a key role of ROCK in efferocytosis dysfunction and the development of ARDS and pulmonary inflammation (13) Moreover, alcoholic subjects are more susceptible to bacterial infection due to impaired phagocytosis function, which was observed in alcoholic hepatitis, sepsis, and lung injury (62, 63). Here, RHOA is linked to alcoholic hepatitis.