The MFI of CTLA-4, LC3II, mTOR, and P62 on CD4+ cells were significantly higher in patients with sepsis than in non-septic patients (185.5 versus 104.4, P<0.0001; 152.3 versus 99.6, P=0.001; 166.8 versus 143.6, P=0.029; and 244.0 versus 177.2, P=0.001, respectively) (Additional File S2). This evidence concerns the gene SQSTM1 and Sepsis.