Consistent with this, Pearson’s analysis identified that CTLA-4 overexpression significantly correlated with LC3II expression in patients with sepsis (R2 = 0.688, P<0.0001), patients with SAI (R2 = 0.678, P<0.0001), and non-surviving patients with SAI (R2 = 0.724, P=0.002) (Figure 5). The gene discussed is CTLA4; the disease is Sepsis.