In addition, the percentage of CD4+ cells expressing CTLA-4 and CTLA-4 MFI on CD4+ cells were also higher among non-surviving patients with sepsis (90.2% versus 50.3%, P<0.0001; and 427.5 versus 130.6, P=0.002, respectively) (Figure 4B; Additional Files S6, S8). This evidence concerns the gene CD4 and Sepsis.