In addition, the univariate analysis also showed that smoking, hypertension, oliguria or anuria, SCr, hemoglobin (Hb), serum IgA, deposit intensity of IgG1 and IgG3 in kidney biopsies, fibro cellular crescents%, crescents%, and electron-dense deposit were significantly associated with the risk of ESRD (p<0.05) (Table 3). Here, IGHG3 is linked to hypertensive disorder.