VEGFA and neoplasm: Additionally, glioblastoma stem cells exosomal miR-374b-3p can also induce macrophages to M2 macrophages, releasing pro-angiogenic factors, including fibroblast growth factor and vascular endothelial growth factor, and leading to the angiogenesis of tumor (38), this will ultimately stimulate the growth of vascular endothelial cells and promote delivering nutrients and oxygen to the growth of tumor (39).