Natural products exert their influence on diverse pathways in lung cancer, inducing ferroptosis through modulation of antioxidant pathways (System Xc−, GPX4, NRF2, FSP1), iron metabolism regulators (TFRC, DMT1, HO-1, Ferritin, NCOA4), lipid metabolism regulators (ACSL4), and mitochondria-dependent processes (VDAC, Calcium influx). The gene discussed is ACSL4; the disease is lung cancer.