The most well-described innate immune checkpoints are the “don't eat me” signals, including the CD47/SIRPα, PD-1/PD-L1, CD52/SIGLEC-10,4 CD24/SIGLEC-10, and HLA-G/LILRBs axis, etc. Expression of CD52 (Fig. 1X) and PD-L1 (Fig. S9A), but not CD24, HLA-G, and CD47 (Fig. S9B–D), are significantly correlated with SETBP1 in AML patients. The gene discussed is SETBP1; the disease is acute myeloid leukemia.