We found out that MIR375 could orchestrate CLCA2 expression by binding to its 3′UTR sequence when the expression of CLCA2 was significantly negatively correlated with the MIR375. By this means, the inhibition of MIR375 can activate the downstream tumor suppressor, CLCA2, thereby impeding the progression of PCa cells. Here, CLCA2 is linked to posterior cortical atrophy.