Resveratrol upregulated SIRT1 and inhibited Akt/mTOR while activating p38-MAPK in NSCLC cells dose-dependently, possibly causing autophagy. Activating the Akt/mTOR pathway with IGF-1 or blocking the p-38-MAPK pathway greatly reduces cell proliferation and increases apoptosis. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.