Meanwhile, the KEGG signaling pathways of BE primarily involved pathways of Lipid and atherosclerosis, Proteoglycans in cancer, Hepatitis B, Yersinia infection, Human cytomegalovirus infection, Chagas disease, Fluid shear stress and atherosclerosis, PI3K-AKT signaling pathway, and Kaposi sarcoma-associated herpesvirus infection (Figure 4H). Here, PIK3CA is linked to Chagas disease.