Monocyte chemo-attractant protein-1 (MCP-1, CCL2) levels are notably elevated in urine samples from patients with active LN, correlating with histological features such as cell crescents, intracapillary hyperplasia, interstitial inflammation, glomerulosclerosis, interstitial fibrosis, and tubular atrophy. The gene discussed is CCL2; the disease is lobular neoplasia.