However, further evaluation in a larger lupus population is necessary (Jog et al., 2016).Catalina Burbano et al. observed that urinary HMGB1+ microparticles differed between patients with active and inactive LN, suggesting that these microparticles in urine are indicative of renal among individuals with systemic lupus erythematosus (Burbano et al., 2019). Here, HMGB1 is linked to systemic lupus erythematosus.