HMGB1 and lobular neoplasia: However, further evaluation in a larger lupus population is necessary (Jog et al., 2016).Catalina Burbano et al. observed that urinary HMGB1+ microparticles differed between patients with active and inactive LN, suggesting that these microparticles in urine are indicative of renal among individuals with systemic lupus erythematosus (Burbano et al., 2019).