C3 and lobular neoplasia: Research also showed a downregulation of miR-3201 and miR-1273e among 2402 urinary microRNAs (miRNAs) in LN patients, correlating with intracapillary glomerular inflammation (Cardenas-Gonzalez et al., 2017).Exosomal miR-146a is negatively correlated with circulating C3 and C4 complement components, proteinuria, and chronic histological features.