FOXP3 and systemic lupus erythematosus: Monitoring urinary sediment mRNA levels of T-bet (key transcription factor of type 1 T helper cells), GATA-3 (key transcription factor of type 2 T helper cells), and FOXP3 (key transcription factor of regulatory T cells) could provide early indicators of disease flares in lupus patients (Szeto, 2017).