IL-16 is associated with the severity of renal inflammatory cell infiltration (Häyry et al., 2022; Fava et al., 2022). IL-17 levels correlate with proliferative LN (Susianti et al., 2015), while IL-18 is linked to a poor prognosis in these patients (Wu et al., 2016). This evidence concerns the gene IL16 and lobular neoplasia.