Silent information regulator 1 (SIRT1) is an energy sensor that controls associated signals like peroxisome proliferator-activated receptor-γ (PPAR-γ) and maintains metabolic homeostasis; along with deacetylates some signals to prevent their transcriptional activity, like NF-κB and HIF-1α, thereby affecting RA (Wu et al., 2021). Here, HIF1A is linked to rheumatoid arthritis.