Mutations in additional sex combs-like 1 (ASXL1), DNA methyltransferase 3 alpha (DMNT3A), isocitrate dehydrogenase (IDH) or SET binding protein 1 (SETBP1) were shown to be associated with CML progression and TKI resistance (Kim et al., 2017). Here, SETBP1 is linked to chronic myelogenous leukemia, BCR-ABL1 positive.