RAPGEF4 and adrenal cortex carcinoma: For heterozygous mutation analysis, amplification rate of genes such as ADCY8, GNB2, GNG11, GNGT1, PRKAR1B, PRKAR2B in ACC, BLCA, BRCA, ESCA, KICH, LUSC, OV, READ, SARC, SARC SKCM, TGCT, UCS were greater than 23%, while deletion rate of GCG, RAPGEF4 KCNS3, GLP-1R, GNG12, GNGT2, ITPR3, GNG5, PRKAR1A in KICH were greater than 43% (Figure 3C).