GNGT1, GNG13 and GNG4 were significantly upregulated in most cancer types, while KCNB1, ADCY5, PRKAR2B, GNG7, GNB3, RAPGEF3, GCG, ITPR1 were downregulated in most cancer types (|log2-fold change| ≥ 1, p < 0.05). This evidence concerns the gene PRKAR2B and cancer.