These factors include male gender, older age, the comorbidity of neoplasm, complications including diastolic hypotension, ALI/ARDS, septic shock, MOF, acute kidney injury, metabolic acidosis, and laboratory results including Scr, BUN, CRP, leukopenia, sodium, albumin, PaO2/FiO2, arterial blood PH, gram-negative microorganism, and multilobar or bilateral involvement. The gene discussed is CRP; the disease is Acidosis.