Subsequent triple-knockout GEMMs (Rb1/Trp53/Pten, Rb1/Trp53/P130) or Rb1/Trp53 knockout GEMMs with Myc, Nfib or Fgfr1 amplification could accelerate the initiation and progression of SCLC in lung epithelial cells [38–44]. This evidence concerns the gene RB1 and small cell lung carcinoma.