Unsupervised clustering analysis of a large panel of SCLC cell lines revealed that insulinoma-associated protein 1 (INSM1), an NE TF, and yes-associated protein 1 (YAP1), a vital mediator activated in the Hippo signaling pathway, may define two subtypes of SCLC [78]. The gene discussed is INSM1; the disease is small cell lung carcinoma.