In summary, the results revealed that circ-AMPK1 in CD105+ CAF-Exos encodes AMPK1-360aa and that AMPK1-360aa, NEDD4, and AMPK1 interact with each other to inhibit the ubiquitination of AMPK1 and p-ULK1, thereby promoting autophagy, proliferation, and metastasis in PC cells (Fig. 7H). Here, PRKAA1 is linked to pachyonychia congenita.