The production of CircGGNBP2, which encodes GGNBP2-184aa, can be induced by IL-6, a protein that has recently been found to interact with STAT3 and promote STAT3 phosphorylation, thus forming an IL-6-STAT3 positive feedback loop that promotes the malignant progression of intrahepatic cholangiocarcinoma [43]. Here, STAT3 is linked to intrahepatic cholangiocarcinoma.