PRKAA1 and pachyonychia congenita: Moreover, circAMPK1 may competitively bind to ubiquitinating enzymes through the encoded protein AMPK1-360aa, which in turn inhibits the ubiquitination-mediated degradation of AMPK1, thus contributing to the upregulation of AMPK1 expression and subsequent induction of cellular autophagy to mediate the malignant progression of PC.