PBS, NF-Exos, CD105+ CAF-Exos and CD105- CAF-Exos were added to PC cells for culture, and the results showed that CD105+ CAF-Exos promoted the proliferation and metastasis of PC cells (Fig. 1J, K and Additional file 2: Fig. S2A-S2B). Here, ENG is linked to pachyonychia congenita.