ENG and pachyonychia congenita: After the incubation of PC cells with PBS, sh-Control-Exos, sh-circAMPK1#1-Exos, or sh-circAMPK1#2-Exos, we found that silencing circAMPK1 in CD105+ CAFs partially reversed the effects of exosomes on the proliferation and invasion of PC cells (Additional file 3: Fig. S3A-S3B).