METTL14 and neoplasm: For example, ovarian cancer cell growth was enhanced in METTL3-cKO mice [43]; while METTL14 overexpression decreased ovarian cancer proliferation by inhibition of TROAP expression via an m6A RNA methylation-dependent mechanism [44].These contradictions may be due to the complex functions of the METTL3/14 genes and the heterogeneity of the tumor.