Among these genes, five (CD34, EMCN, HLA-G, PDPN, and TEK) showed hypermethylated DMRs mapped to promoter regions, and three exhibited hypomethylated DMRs (gene body/3` UTR of HLA-DOA, and gene bodies of HLA-DQA2 and ICOSLG) in IBC. The gene discussed is ICOSLG; the disease is inflammatory breast carcinoma.