Work in mouse models has shown that the Cux1 gene plays an important role during the development of the upper layer of the brain cortex [5], and in humans variants in CUX1 or its cis-regulatory regions have been associated with a variety of neurodevelopmental conditions or neurodiversity ranging from autism spectrum disorders (ASD) to developmental delay and intellectual disability [6, 7]. This evidence concerns the gene CUX1 and Intellectual disability.