LT-α binds to TNF receptors TNFR1 and TNFR2 in its homotrimeric form, and to TNFR3 in its heterotrimeric form with LT-β/TNFC; all three TNF receptors have been shown to be associated with progression of DKD [46, 47]. The gene discussed is TNFRSF1B; the disease is diabetic kidney disease.