LT-α binds to TNF receptors TNFR1 and TNFR2 in its homotrimeric form, and to TNFR3 in its heterotrimeric form with LT-β/TNFC; all three TNF receptors have been shown to be associated with progression of DKD [46, 47]. This evidence concerns the gene LTB and diabetic kidney disease.