Human genetic studies identify CTNNB1 as a high-confidence risk gene for ID and autism (https://gene.sfari.org/database/human-gene/CTNNB1) (Caracci et al, 2021; Cederquist et al, 2020; de Ligt et al, 2012; Deciphering Developmental Disorders, 2017; Dubruc et al, 2014; Hormozdiari et al, 2015; Iossifov et al, 2014; Krumm et al, 2014; Kuechler et al, 2015; O’Roak et al, 2012a; O’Roak et al, 2012b; Packer, 2018; Satterstrom et al, 2019; Tucci et al, 2014). The gene discussed is CTNNB1; the disease is autism.