GDF15 and neoplasm: When assessing for the impact of increased expression of GDF15 on survival, we found associations between low GDF15 and improved outcome at the protein level in tissue (Fig. 4H,I), and in two independent public transcriptomic datasets (Appendix Fig. S4C,D), suggesting that GDF15 contributes to tumor progression in CRC, in accordance with previous studies (Wallin et al, 2011a; Brown et al, 2003).