With high GDF15, Treg infiltration, and CD8 T-cell dysfunction all being shown to be associated with poor prognosis in CRC (Wallin et al, 2011b; Jobin et al, 2017; Betts et al, 2012) (GDF15 being additionally associated with recurrence (Wallin et al, 2011a)), and with the majority of CRC patients being treated with oxaliplatin, we next considered whether the TXNIP/GDF15 axis, an axis which should regulate these processes to the benefit of the patient, remained functional in metastatic disease. Here, TXNIP is linked to metastatic neoplasm.