For example, chemotherapy-induced immunogenic cell death (ICD) leads to cells exposing or releasing damage-associated molecular patterns (DAMPs), such as HSP70, calreticulin, ATP, high-mobility group box 1 (HMGB1), type I IFN, and cancer cell-derived nucleic acids (Galluzzi et al, 2018; Krysko et al, 2012). This evidence concerns the gene HMGB1 and cancer.