In C57BL/6 mice, infection with 100 iRBC led for all nine tested mutants to a delayed infection that could be fully controlled and cleared by the mice infected with U2 snRNP(−), dgk(−), hgprt(−), app(−), and lap(−) parasites (Figs. 1C and 2A–C; Table EV1, Appendix Fig. S7 and Appendix Table S6). The gene discussed is APP; the disease is infection.