Given the close functional links between the MAPK and Hippo pathways in transcription and cancer (Herranz et al, 2012; Koo et al, 2020; Lin et al, 2015; Park et al, 2020; Pascual et al, 2017; Pham et al, 2021; Reddy and Irvine, 2013; Stein et al, 2015; Zanconato et al, 2015), we investigated this in NF1 mutant H2052 cells, which displayed MAPK pathway activation (Fig. 3F). This evidence concerns the gene NF1 and cancer.