The discovery of several protein degradation components as hits for rescuing mutant Tg secretion may suggest that the blockage of degradation pathways can broadly rescue the secretion of A2234D and C1264R mutant Tg, a phenomenon similarly found for destabilized CFTR implicated in the protein-folding disease cystic fibrosis (Vij et al, 2006; Pankow et al, 2015; McDonald et al, 2022). Here, CFTR is linked to cystic fibrosis.