There were significant differences in IBD patients’ laboratory data when compared according to IBD activity status; fecal calprotectin (p-value < 0.001), CRP (p-value = 0.009), and ESR (p-value < 0.001) levels significantly increased while miR-146a expression level significantly decreased (p-value < 0.001) in IBD patients with active disease compared to those with inactive disease. The gene discussed is ESR1; the disease is inflammatory bowel disease.