NPM1 and colitis: Moreover, in Npm1+/− mice exposed to DSS, bezafibrate resulted in increased percentages of total colonic ILC3s, IL-22+ ILC3s and IL-22 production by ILC3s (Fig. 4o–q), suggesting that sufficient mitochondrial OXPHOS and biogenesis are required for ILC3 activity in DSS-induced colitis.