Because RORc-Cre will also delete Npm1 in conventional T cells and γδT cells, we examined the function of various T cell subsets and excluded their contributions to exacerbated colitis in Rorccre/+Npm1flox/flox mice by depleting T cells using a CD3 antibody (Extended Data Fig. 6i–q). This evidence concerns the gene NPM1 and colitis.