Results indicated that the ratio of Lin−c-Kit+ (LK) cells, Lin−Sca1+c-Kit+ (LSK) cells and LSlowKlow cells in the BM of Npm1+/− mice was elevated compared with that of Npm1+/+ mice both in steady state and DSS-induced colitis conditions (Extended Data Fig. 1o,p), which is a characteristic phenotype of MDS21,31,32. Here, NPM1 is linked to colitis.