In SW837 tumors, combination with either BI-3406 (P = 0.003 at 4, 24 and 48 h) or cetuximab (P = 0.002, 0.003 and 0.003 for 4, 24 and 48 h, respectively) further downregulated Ki-67 when compared to levels by adagrasib alone at 4 h after the last dose (Extended Data Fig. 6b); however, no treatment further decreased p-ERK levels when compared to levels induced by adagrasib alone at 4 h in this model (Extended Data Fig. 6b), which is consistent with multiplex immunofluorescence results in the F3008 CRC PDX model (Fig. 5d). The gene discussed is MKI67; the disease is colorectal carcinoma.