MAPT and Alzheimer disease: Evidence increasingly implicates regulation of microglia activation in several AD-related processes including plaque formation and growth [11], plaque compaction [11, 12], protection against dystrophic neurites [13], regulation of development and spread of Tau pathology [14], destruction of perineuronal nets [15, 16], and synaptic and neuronal loss [15, 17–20], though the role of microglia in suppressing or aggravating impacts of AD is currently unclear, and may vary with disease progression [21].