Of these, the most interesting are Wfs1, recently implicated in Tau clearance in AD [67], which is downregulated in Trem2R47H; 5xFAD compared with 5xFAD, and Grm2, a glutamate receptor downregulated in Trem2R47H; 5xFAD compared with 5xFAD in L3 IT and L6 IT neurons. This evidence concerns the gene GRM2 and Alzheimer disease.