Thalamic excitatory neurons exhibit 5xFAD induced upregulation of Grin2c, Epha10, Ptpru, and Crtac1, with downregulation of Syp, Bdnf, Negr1, and Gsto1, each of which has been linked to AD [70–76]. The gene discussed is GRIN2C; the disease is Alzheimer disease.