RPL40 also exhibited a similar, though less pronounced, trend (Supplementary information, Fig. S7c), consistent with the notion that the expression of ribosomal proteins is generally elevated in cancer.27 Further analysis revealed that RPL40 K22me3 not only correlated strongly with the RPL40 level but also with the SMYD5 level in these human HCC samples (Supplementary information, Fig. S7e, f). The gene discussed is SMYD5; the disease is cancer.