The intensity of SMYD5 staining inversely correlated with overall survival and disease-free survival rates (Supplementary information, Fig. S7d), consistent with previous reports (Supplementary information, Fig. S1).13,14 Like SMYD5, RPL40 K22me3 is elevated in 53.4% and attenuated in 5.0% of the tumor (T) samples compared to adjacent paratumor (P) tissues (Supplementary information, Fig. S7c). This evidence concerns the gene UBA52 and neoplasm.