SMYD5 and cancer: Indeed, data from the TCGA database indicate that SMYD5 mRNA levels are elevated in most cancer types with HCC being one of the most significant types (Supplementary information, Fig. S1a).11,12 Consistently, two recent multi-omics studies have found that both SMYD5 mRNA and protein levels are significantly elevated in HCC samples and are associated with poor clinical outcomes (Supplementary information, Fig. S1b–e).13,14