SMYD5 and Hepatic fibrosis: Animals with liver-specific SMYD5 depletion (AlbCre;Smyd5loxP/loxP) developed normally without any notable phenotype, aligning with data from International Mouse Phenotyping Consortium (IMPC, Supplementary information, Table S4) showing that full body Smyd5 KO mice are viable, fertile and exhibit only minor phenotypes.28,29 We utilized a model based on a two-stage chemical application to initiate and promote hepatocellular tumors in association with advanced liver fibrosis.