TBK1 missense mutations also cause ALS and FTD (Freischmidt et al, 2015; Gijselinck et al, 2015; Hirsch-Reinshagen et al, 2019; Pottier et al, 2015; Van Mossevelde et al, 2016). This evidence concerns the gene TBK1 and frontotemporal dementia.