OPTN and amyotrophic lateral sclerosis: It was previously shown that the ALS and FTD-associated TBK1-E696K mutant leads to loss-of-function phenotypes related to mitophagy due to reduced interaction with optineurin (Harding et al, 2021; Li et al, 2016; Moore and Holzbaur, 2016; Pottier et al, 2015).