Placing TBK1 in this nutrient-dependent pathway for mTORC1 activation may be of relevance for the anabolic effects of TBK1 in the context of diabetes and obesity (Bodur et al, 2022; Cruz et al, 2018; Oral et al, 2017; Reilly et al, 2013). Here, TBK1 is linked to obesity due to melanocortin 4 receptor deficiency.