Consistently, congenital mutations of the human PQBP1 gene cause intellectual disability and microcephaly (Kalscheuer et al, 2003; Stevenson et al, 2005), and acquired PQBP1 dysfunction causes neuronal synapse loss in Alzheimer’s disease (Tanaka et al, 2018). This evidence concerns the gene PQBP1 and early-onset autosomal dominant Alzheimer disease.