Moreover, intracellular Aβ accumulation in Alzheimer’s disease (AD) or intracellular TDP43 accumulation in frontotemporal lobar degeneration (FTLD) is associated with senescence phenotypes (Tanaka et al, 2020; Homma et al, 2021), while the mechanism underlying the link between intracellular disease protein accumulation and senescence is not completely understood. The gene discussed is TARDBP; the disease is Alzheimer disease.