As previously demonstrated for PQBP1 in the contexts of SCA1, HD, and AD (Waragai, 1999; Okazawa et al, 2002; Tanaka et al, 2018; Jin et al, 2021), PQBP3/NOL7 could function as an additional hub molecule in common pathologies across multiple neurodegenerative diseases. This evidence concerns the gene ATXN1 and neurodegenerative disease.