NOL10 and neurodegenerative disease: Moreover, PQBP5/NOL10 is sequestered to the inclusion bodies of polyQ disease proteins, which is the common mechanism of the polyQ category of neurodegenerative diseases (Perutz, 1999; Wanker, 2000; Chai et al, 2002; Stenoien et al, 2002; Kim et al, 2002).