For example, elevated plasma levels of intercellular adhesion molecule 1 (ICAM-1), a transmembrane protein that is being upregulates under conditions of stress or injury, associated with connective tissue diseases17 and correlated to disease activity in patients with RP due to scleroderma18 have been shown in an experimental study in vibration exposed individuals19 and in vibration injured patients compared to controls20. Here, ICAM1 is linked to retinitis pigmentosa 1.